EEG & TMS

Push the boundaries of your TMS research!

Transcranial magnetic stimulation (TMS) is a non-invasive technique that allows stimulation through the intact skull bone and can activate, inhibit or temporarily deactivate selected brain regions. TMS can be combined with EEG to investigate cortical reactivity and connectivity. The PowerMAG research stimulator is a solution specially designed for rTMS stimulation during EEG recording. Innovative hardware solutions implemented in the PowerMAG research allow the TMS stimulator to be phase synchronized with the EEG amplifiers and continuous EEGs to be recorded without any power line noise or recharging artifacts.

The PowerMAG research and the BrainAmp DC system can be used separately or combined in the following fields of application:

PowerMAG research TMS Stimulator

• Neurology, psychiatry, neuroscience, rehabilitation
• Clinical examinations (central and peripheral nervous system)
• Therapeutic applications (depression, tinnitus, stroke)

BrainAmp DC System

• BCI, Behavior, EEG, ERP
• EEG/MEG, EEG/TMS
• Neurofeedback, Sleep studies

PowerMAG research TMS Stimulator & BrainAmp DC System

• Evoked potentials analysis (TEPs) measured at the cortical level to asses cortical reactivity and connectivity
• Analysis of TMS stimulation effects on functional networks during cognitive tasks
• Interaction of TMS stimulation with oscillatory brain activity in order to understand the causal relationship
between cortical rhythms and perceptual, cognitive or motor processes

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PowerMAG research - two models of stimulator!

• PowerMAG research 30 - no compromises at high frequencies.
  Maximum intensity (100% output) in the entire frequency range of up to 30 Hz.
• PowerMAG research 100 for theta burst stimulation.
  Bursts up to 100 Hz are applied with constant intensities by recharging between pulses

Features of both PowerMAG research models:

• Operating time: Optimized stimulator design slows coil heating, allowing up to 3000 pulses without external cooling. Special conductor construction allows slim coil design and flexible cable.
• Precision: Accurate control system allows precise dosage of the powerful pulses. Near-threshold stimulation with maximum reproducibility is guaranteed.
• Navigated TMS: Visualization of the electromagnetic field of the PowerMAG research coils on an individual anatomical dataset for a precise and reproducible application.
• Flexible control: Simple and quick operation from the front panel. Sophisticated protocols can be written using third party stimulation software such as Presentation and E-Prime and applied via an external interface.

More information on the PowerMAG research can be found on the PowerMAG research Product Details Page.

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Stimulation Coils: Variety of stimulation coils

A variety of stimulation coils allow the PowerMAG research to be adapted to the specific field of application.

• Precision coil:
  Highly focal stimulation up to 1 Hz, suitable for multifocal applications due to its compact construction. Highly focal field distribution with sharpened peak efficiency.
• Double coil:
  Focal stimulation, suitable for selective stimulation of individual areas. Sharp field distribution maximum due to the summation effect in the coil’s center.
• Circular coil:
  Large-area stimulation, suitable for peripheral and cortical applications. High penetration depth through widespread field distribution.

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BrainAmp DC & SyncBox

BrainAmp DC
It is well known that recording neurophysiological data during TMS stimulation is a technically challenging task. TMS stimulation induces a very strong electrical field that can saturate the recording amplifiers for a long duration. Furthermore, even if the amplifier does not reach saturation point, the TMS pulse induces an artifact in the EEG data that can last for hundreds of milliseconds. The BrainAmp DC amplifier is a solution that is particularly suited to EEG and rTMS. Thanks to its software-selectable operating range, the BrainAmp DC can work in very high electromagnetic fields without saturation.

This outstanding feature makes it possible to record neurophysiological data without blocking the amplifier and therefore without any loss of physiological information. Moreover, the amplifier’s high sampling frequency (up to 5000 Hz) and the wide hardware bandwidth (from DC to 1000 Hz) together minimize ripple and therefore the duration of the TMS artifact.

Recently published scientific articles suggest that with BrainAmp DC, physiological activity is visible just 5 ms after TMS stimulation.

More information on the BrainAmp DC can be found on the BrainAmp DC Product Details Page.

SyncBox
The SyncBox is a tool which synchronizes the clock of the BrainAmp DC system with the PowerMAG research‘s clock.

Phase synchronization between the EEG and the TMS equipment results in temporal stability of the EEG acquisition in relation to the switching of the pulses during TMS stimulation. This leads to a significant improvement in the quality of the recorded data and opens up new and unique opportunities to develop methods for TMS artifact removal.

More information on the SyncBox can be found on the SyncBox Product Details Page.

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Brain Products caps that are designed for EEG and TMS recordings are fitted with Ag/AgCl pellet pin electrodes and have very thin electrode holders (less than 4 mm). This solution allows the TMS coil to be placed very close to the scalp and elicits the evoked response with low magnitude stimulus.

In the standard cap version, every electrode can be freely rotated, thus always allowing the best cable geometry for any stimulation point, a crucial feature for successful EEG recordings during TMS stimulation. In fact, it has been proved that a cleaner signal can be recorded by orienting the cables away from the coil or coil cable.

A special version particularly suitable for working with a large number of channels or with an identical TMS stimulation point is also available on request.

More information on the Fast'nEasy Cap can be found on the Fast'nEasy Cap Product Details Page.

 

 

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BrainVision Recorder & RecView
BrainVision Recorder is a multifunctional recording software product designed to provide our amplifier customers with an extremely versatile and easy-to-use platform for setting up and running recordings. A very convenient wizard-based menu structure simplifies these crucial steps, guiding the user through the entire hardware setup process and hardware/software filter configuration.

The acquisition parameters and the impedance check are automatically stored and can be accessed from within the analysis software at any time. The BrainVision Recorder software even allows evoked potential analysis to be carried out in real time and stores the segmented/averaged data together with the raw data.

The Recorder software can be used in combination with BrainVision RecView. The latter is an advanced solution designed for real-time analysis of data received over an Ethernet network via TCP-IP.

The BrainVision RecView software has a very flexible structure and can be enhanced by functions developed directly by the endusers at any time. Researchers working in the field of EEG and TMS may, for example, develop their own solution to trigger the PowerMAG research on a specific EEG event.

More information on these Software programs can be found on the BrainVision Recorder Product Details Page and the BrainVision RecView Product Details Page.

BrainVision Analyzer 2
BrainVision Analyzer 2 is Brain Products’ new solution for neurophysiological data analysis. Thanks to its ease of use, the handling of an amazing number of powerful features is a snap. The editable history tree lets you organize, explore and trace evaluation steps. Automated analysis with drag & drop functions speeds up recurring tasks.
Various data format readers recognize files from different EEG manufacturers automatically and guarantee compatibility and exchange-ability with research labs all over the world.

The Analyzer includes all necessary preprocessing functions, enhanced time-frequency analysis options, ICA, LORETA, MRI correction as well as a direct interface to MATLAB®. New views offer unlimited output options for publishing your results. Programming interfaces in .NET languages can be used to expand functionality.
With its powerful features and flexibility, the Analyzer 2 software is the perfect solution for scientists aiming at developing methods for TMS artifact removal.

More information on Analyzer 2 can be found on the BrainVision Analyzer 2 Product Details Page.

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Brochure

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Manuals, Tutorials and Downloads (for registered users only)

Press Release Articles